Friday, February 15, 2008

How Do Drugs Work - Antibiotics - Penicillins

Hello Everyone,

Today we are going to discuss the Penicillins. There are several different types of penicillins, however, they have all the same basic mechanism of action (MOA).

Natural Penicillins
• Penicillin G
• Penicllin G procaine
• Penicillin G benzathine
• Penicillin VK

Penicillinase-resistant Penicillins
• Nafcillin
• Dicloxacillin

Aminopenicillins
• Amoxicillin
• Ampicillin

Carboxypenicillins
• Ticarcillin

Ureidopenicillins
• Piperacillin

Penicillin B-Lactamase inhibitors
• Amoxicillin-clavulanic acid
• Ampicillin-sulbactam
• Ticarcillin-clavulanic acid
• Piperacillin- tazobactam v

Mechanism Of Action (bactericidal/bacteriostatic) - Penicillins act by inhibiting bacterial cell wall synthesis. They inhibit enzymes that create a cross-linkage between the bacterial peptide chains and prevent the formation of the bacterial cell wall. These enzymes are the penicillin-binding proteins.

Spectrum (Gm+, Gm-, anaerobes) Gram +: streptococci, Enterococcus, but NOT
S. aureus. Gram - : only a few (E. coli, Proteus spp, a few others)…lots of resistance

No below-the-diaphragm anaerobic activity

I f you would like some more in-depth inormation on penicillins or antibiotics in general you can check out:

http://www.surgicalcriticalcare.net/Lectures/antibiotics.pdf
http://students.washington.edu/rhochi/antibiotics.pdf

Next post will cover the the cephalosporins.

Stay well.....

Dr. Paul

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